We describe two siblings from a consanguineous family with autosomal recessive Fanconi's syndrome and hypophosphatemic rickets. Genetic analysis revealed a homozygous in-frame duplication of 21 bp in ...

Current renal substitution therapy with hemodialysis or hemofiltration has been the only successful long-term ex vivo organ substitution therapy to date. Although this approach is life sustaining, it ...

In renal Fanconi's syndrome, dysfunction in proximal tubular cells leads to renal losses of water, electrolytes, and low-molecular-weight nutrients. For most types of isolated Fanconi's syndrome, the ...

Every day our kidneys tackle the daunting task of continuously cleaning our blood to prevent waste, salt and excess fluid from building up inside our bodies. To achieve this, the kidneys' ...

Excessive phosphate loading within the proximal tubular lumen has been proposed as a key mechanism driving progression of chronic kidney disease (CKD) through calcium phosphate microcrystallopathy.

Please provide your email address to receive an email when new articles are posted on . Patients who had cardiac surgery had high levels of transforming growth factor-beta 2. The cohort also had ...

Transform your drug development pipeline with Newcells’ Renal Proximal Tubule Cells Model eBook. This eBook provides insight into the science behind aProximate ™, an innovative proximal tubule cell ...