During embryonic development, cells start out as pluripotent, or have the potential to become many different cell types through differentiation. Naive-state is the name for the earliest stage of ...

If you look at a nerve cell, a muscle cell, or a skin cell under the microscope, they appear strikingly different. However, every cell in our body has the same DNA and has descended from a common ...

The human genome contains about 23,000 genes, but only a fraction of those genes are turned on inside a cell at any given time. The complex network of regulatory elements that controls gene expression ...

Genome-wide association studies (GWASs) have linked genetic variants to neuropsychiatric disorders, but their regulatory roles in non-coding regions remain largely unclear. Using the LUHMES neuronal ...

Scientists usually study the molecular machinery that controls gene expression from the perspective of a linear, two-dimensional genome—even though DNA and its bound proteins function in three ...

A new class of AAVs has arrived. In six coordinated studies published on 21 May across Neuron, Cell, Cell Reports, and Cell Reports Methods, scientists unveil viral vectors fitted with ...

(L to R) Corresponding author Brian Abraham, PhD, and co-first authors Kelsey Maher, PhD, and co-first author Jie Lu, PhD, all of the St. Jude Department of Computational Biology. Cells express ...